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KMID : 1149220020100020225
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Korean Journal of Oriental Medical Prescription
2002 Volume.10 No. 2 p.225 ~ p.241
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Inhibitory effects of Injinseulki on Chemical-induced hepatic fibrosis in Rats
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Jang Seon-Il
Kim Hyeong-Jin
Hwang K.M.
Kwon Tae-Oh
Jekal Seung-Joo
Kim Youn-Chul
Pae Hyeon-Ok
Choi B.M.
Shim J.S.
Kwak Jun-Soo
Chung Hun-Taeg
Yun Young-Gab
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Abstract
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The inhibitory effects of Injinseulki including extracts of melanian snail plus phytomedicinal plants on CCl4 induced fibrosis, IFN-γ plus LPS-induced production of NO, PMA-stimulated production O2, and tacrine-induced hepatic injury were investigated in rats, RAW 264.7 or HepG2 cells. The ethanol extracts of melanian snail significantly inhibited tarcrine-induced inury of HepG2 cells. Injinseulki inhibited the production of NO and O2 in a dose-dependent manner in activated RAW 264.7 macrophages. Injinseulki significantly inhibited chemical-induced fibrosis in Rats. These results show that Injinseulki including extracts of melanian snail plus phytomedicinal plants may explain some known biological activities of Injinseulki including their anti-inflammatory and anti-fibrotic effect, and is of considerable benefit in the treatment for live diseases.
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KEYWORD
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Injinseulki, fibrosis, nitric oxide (NO), supeoxide anion(O2)
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